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Bone Scan (Tc-99m MDP, Whole Body +/- SPECT)

NM+ ContrastWhole Body
Indications
  • Metastatic disease screening (breast, prostate, lung)
  • Occult or stress fracture
  • Osteomyelitis
  • Avascular necrosis
  • Complex regional pain syndrome
  • Evaluation of bone pain of unknown etiology
  • Prosthesis loosening or infection
Patient prep
  • No specific fasting required
  • Encourage oral hydration after injection (~16 oz) to improve target-to-background
  • Void immediately before imaging to clear bladder activity
  • Remove metal objects from imaging field
Contrast
AgentTc-99m MDP (methylene diphosphonate) or Tc-99m HDP
RouteIV
Dose20-25 mCi (740-925 MBq); range 10-30 mCi
TimingDelayed imaging 2-4 hours after injection (allows soft-tissue clearance)
Technique
  • Large field-of-view gamma camera, low-energy high-resolution (LEHR) collimator, 140 keV photopeak with 15-20% window
  • Whole-body anterior/posterior sweep at 10-15 cm/min, or multiple spot views
  • SPECT or SPECT/CT for problem-solving (e.g., spine, pelvis, joints)
Series / Sequences
#Series / SequencePlaneNotes
1Whole-body anteriorCoronal sweepPatient supine, arms at side
2Whole-body posteriorCoronal sweepSimultaneous with anterior on dual-head
3SPECT/CT (optional)Axial/multiplanarLocalization of equivocal lesions
Key points
  • Ensure adequate hydration and voiding to reduce bladder artifact and improve image quality
  • Recent bisphosphonate or chemotherapy may alter uptake; flare phenomenon can mimic progression
  • Superscan (diffuse intense uptake with faint kidneys) suggests widespread metastases
  • Contamination from urine can mimic lesions; have patient void and re-image if suspicious
References
• SNMMI Procedure Standard for Bone Scintigraphy 4.0 (J Nucl Med Technol 2018;46:398) link
• ACR-SPR-SSR Practice Parameter for Skeletal Scintigraphy
• Radiopaedia: Bone scan link
Source: Researched — verify against your institution
Reference template — verify and adapt to your scanner, vendor and institution before clinical use. Not a substitute for clinical judgment.