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GI Bleeding Scan (Tc-99m Labeled RBC)

NM+ ContrastAbdomen & Pelvis
Indications
  • Localization of active lower GI bleeding
  • Intermittent / obscure GI hemorrhage
  • Detection of bleeding too slow for angiography (>0.1-0.2 mL/min)
Patient prep
  • No fasting required (study is often urgent)
  • Patient should be actively bleeding for positive study
  • IV access; obtain blood for in vitro/modified in vivo RBC labeling
Contrast
AgentTc-99m labeled autologous red blood cells (in vitro UltraTag preferred)
RouteIV
Dose20-25 mCi (740-925 MBq)
TimingDynamic imaging begins immediately; delayed/intermittent imaging up to 24 h for intermittent bleeds
Technique
  • LEHR collimator, 140 keV, anterior abdomen/pelvis in FOV
  • Flow phase 1-5 sec/frame for 60 sec, then dynamic 1-2 min/frame for 60-90 min
  • Cine review to detect appearance and antegrade/retrograde movement of activity
  • Delayed images if no early bleed; re-image when symptoms recur
Series / Sequences
#Series / SequencePlaneNotes
1Flow phaseAnteriorVascular/blood pool baseline
2Dynamic blood poolAnterior1-2 min/frame x 60-90 min; watch for focus that moves with bowel
3Delayed imagesAnteriorUp to 24 h for intermittent bleeding
Key points
  • Bleeding identified as a focus of activity appearing on serial images that conforms to and moves within bowel lumen
  • Cine review is essential to localize and distinguish bowel from fixed blood-pool structures (vessels, kidneys, bladder)
  • More sensitive than angiography for slow/intermittent bleeding
  • Good RBC labeling efficiency critical; free pertechnetate causes gastric/GU/thyroid activity (false interpretation)
References
• SNMMI Procedure Guideline for Gastrointestinal Bleeding Scintigraphy
• Radiopaedia: GI bleeding scintigraphy link
Source: Researched — verify against your institution
Reference template — verify and adapt to your scanner, vendor and institution before clinical use. Not a substitute for clinical judgment.