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Hysterosalpingogram (HSG)

Fluoro+ ContrastOB-GYNverify
Indications
  • Infertility workup — tubal patency assessment
  • Recurrent pregnancy loss (uterine cavity evaluation)
  • Suspected uterine anomaly (septate, bicornuate, unicornuate)
  • Assessment of tubal occlusion devices / post-tubal ligation or reversal
  • Intrauterine adhesions (Asherman), polyps, submucosal fibroids
Patient prep
  • Schedule in proliferative phase, days ~7-12 of cycle (after menses, before ovulation)
  • Exclude pregnancy and active pelvic infection/STI; pregnancy test
  • Consider pre-procedure NSAID for cramping; antibiotic prophylaxis if hydrosalpinx or PID history per protocol
  • Empty bladder before exam
Contrast
AgentWater-soluble iodinated contrast (e.g., Omnipaque 240/300 body cavity formulation)
Routetranscervical via cannula/balloon catheter into uterine cavity
DoseSlow injection of ~5-20 mL until uterine cavity fills and tubes opacify with peritoneal spill
TimingReal-time fluoroscopy during slow injection
Technique
  • Sterile speculum exam; cannulate/cervix occlude with balloon or cervical cup
  • Inject contrast slowly under fluoroscopy to outline the endometrial cavity
  • Document cavity contour, then continued filling to opacify fallopian tubes
  • Capture free intraperitoneal spill (confirms patency)
  • Oblique/spot images to separate tubes and define cornua; delayed image for spill if needed
Series / Sequences
#Series / SequencePlaneNotes
1ScoutAP pelvisBaseline, calcifications
2Early cavity fillAPCavity contour — filling defects, anomalies
3Full fill with tubesAP + obliquesTubal course, hydrosalpinx, occlusion
4Free peritoneal spillAPConfirms tubal patency
Key points
  • Strictly avoid in pregnancy, active pelvic infection, and within ~6 months of pregnancy termination; do not perform during menstruation
  • Time to early follicular/proliferative phase to minimize pregnancy risk and improve cavity assessment
  • Watch for venous/lymphatic intravasation (excess pressure) — stop injecting
  • Oil-soluble contrast has shown improved fertility outcomes in some studies but water-soluble is standard for diagnostic clarity and safety; oil agents carry granuloma/embolism risk
  • Antibiotic prophylaxis if dilated tubes/hydrosalpinx (infection risk)
References
• ACR–SPR Practice Parameter for the Performance of Hysterosalpingography
• Omnipaque (iohexol) prescribing information — hysterosalpingography indication (GE Healthcare USPI)
• Radiopaedia: Hysterosalpingography
Source: Researched — verify against your institution
Reference template — verify and adapt to your scanner, vendor and institution before clinical use. Not a substitute for clinical judgment.