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CTA Chest — Pulmonary Embolism (CTPA)

CTA+ ContrastVascular
Indications
  • Suspected acute pulmonary embolism (elevated D-dimer / Wells score, pleuritic pain, dyspnea, hypoxia)
  • Suspected chronic thromboembolic disease
  • Right heart strain assessment in known PE
  • Follow-up of treated PE when clinically indicated
Patient prep
  • Screen eGFR/contrast allergy; premedicate if indicated
  • Large-bore IV (18-20 G, antecubital preferred) for high flow rate
  • Coach a SHORT end-inspiratory or quiet breath-hold (deep inspiration can draw unopacified IVC blood causing transient interruption artifact)
  • Supine, arms up
Contrast
Agentiodinated, high concentration (e.g. iohexol 350 or iopamidol 370)
RouteIV
Dose≈60-100 mL at 4-5 mL/s followed by saline flush
TimingBolus tracking with ROI in main pulmonary artery, trigger ~100-150 HU; or test bolus / SmartPrep ~ pulmonary arterial peak (~6-10 s post threshold)
Technique
  • Supine, arms up; helical volume from lung apices through diaphragm/costophrenic angles (caudo-cranial often used to reduce respiratory motion at bases)
  • 100-120 kV (lower kV, e.g. 80-100 kV, improves iodine conspicuity and lowers dose/contrast volume); mAs per scanner with AEC
  • Thin reconstruction (0.625-1 mm) for subsegmental arteries; soft-tissue and lung kernels
  • Coronal/sagittal reformats; optional thin MIP along vessels
  • Iterative reconstruction; bolus tracking in main PA
Series / Sequences
#Series / SequencePlaneThicknessNotes
1Axial PA-phase (soft tissue)axial0.625-1.25 mmStandard kernel; evaluate to subsegmental level for filling defects
2Axial lungaxial1-1.5 mmLung kernel; infarct, alternative diagnosis
3Coronal/sagittal reformatcoronal2-3 mmVessel course, clot burden
4Thin MIP (optional)axial5-10 mmVessel tracking
Key points
  • Optimal timing targets PEAK pulmonary arterial enhancement (not systemic) — bolus tracking ROI in the main PA is key; mistimed studies are the main cause of nondiagnostic exams
  • Lower kV (80-100) boosts iodine signal, enabling reduced contrast volume
  • Assess RV strain: RV/LV diameter ratio >1.0, septal bowing, contrast reflux into IVC/hepatic veins
  • Suboptimal breath-hold causes transient interruption of contrast bolus at the lung bases — caudocranial scanning and short breath-hold help
References
• ACR–NASCI–SPR Practice Parameter for the Performance and Interpretation of Cardiac CT / Thoracic CTA
• ACR Appropriateness Criteria: Suspected Pulmonary Embolism
• Radiopaedia: CT pulmonary angiogram (protocol) link
• RadioGraphics: CT Pulmonary Angiography — Technique and Pitfalls
Source: Researched — verify against your institution
Reference template — verify and adapt to your scanner, vendor and institution before clinical use. Not a substitute for clinical judgment.